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CS-W001157 4
Total: USD 88.00

2,8-Quinolinediol

  • CAS No. 15450-76-7

  • Cat. No. CS-D1708
  • Purity≥98%
  • MDL No.MFCD00216696

*For research and further manufacturing use only, not for direct human use.

2,8-Quinolinediol|CS-D1708

Structure of 15450-76-7

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General Information

  • CAS No. 15450-76-7
  • Cat. No. CS-D1708
  • Purity ≥98%
  • MDL No. MFCD00216696
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇NO₂
  • Molecular Weight 161.16
  • Synonym(s) 2,8-Dihydroxyquinoline; 8-Hydroxycarbostyril
  • SMILES O=C1NC2=C(C=CC=C2O)C=C1

Description

2,8-Quinolinediol is a quinolone derivative. It has been reported as metabolite of 8-hydroxyquinoline-N-oxide in rabbits. Synthesis of 2,8-quinolinediol has been reported. It is reported as one of the six possible forms of 8-hydroxycarbostyril. It has been detected as new UV-absorbing compound (UAC) in cow milk and its structure was elucidated using HRMS and by 1H, 13C and 1H 13C NMR.It is also known as 8-hydroxycarbostyril or 8-hydroxyquinolin-2(1H)-one.2,8-Quinolinediol is suitable for use as standard in a study to identify the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats by online and off-line LC-MS techniques. It may be used as starting reagent for the preparation of two powerful 2-adrenergic receptor agonists, used for the treatment of asthma:ProcaterolIndacaterol

Synthesis

  • Route1
    • 2-Hydroxyquinolin-8-yl acetate|CS-0216708
      15450-72-3
    • ~95%
    • In-stock
      2,8-Quinolinediol|CS-D1708
      15450-76-7

    References

    • Sigouin, Olivier; Beauchamp, Andre L. Canadian Journal of Chemistry, 2005 , vol. 83, # 5 p. 460 - 470
  • Route2

    References

    • Monatshefte fuer Chemie, , vol. 16, p. 761
  • Route3

    References

    • Yakugaku Zasshi, , vol. 71, p. 784 Chem.Abstr., , p. 4007 Yakugaku Zasshi, , vol. 78, p. 697,698 Chem.Abstr., , p. 18406

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   1.2337
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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