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Structure of 154258-82-9
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3-(4-Fluorophenyl)-1H-pyrazole is a bench-stable heterocyclic scaffold featuring a fluorinated aryl group that enhances electron-withdrawal and metabolic stability. This compound integrates readily into medicinal chemistry libraries, serving as a key building block for kinase inhibitors and CNS-targeted therapeutics due to its favorable bioavailability and hydrogen-bonding capacity.
3-(4-Fluorophenyl)-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its fluorinated aryl substituent enhances metabolic stability and modulates electronic properties, while the pyrazole core offers robust functional group tolerance and facilitates hydrogen bonding interactions in target binding. The compound exhibits excellent bench stability and is readily purified by crystallization or chromatography, making it ideal for iterative synthesis campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: