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CS-W001157 4
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1-(3-Bromo-5-chlorophenyl)ethanone

  • CAS No. 154257-85-9

  • Cat. No. CS-0041765
  • Purity≥96%
  • MDL No.MFCD13189467

*For research and further manufacturing use only, not for direct human use.

1-(3-Bromo-5-chlorophenyl)ethanone|CS-0041765

Structure of 154257-85-9

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General Information

  • CAS No. 154257-85-9
  • Cat. No. CS-0041765
  • Purity ≥96%
  • MDL No. MFCD13189467
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrClO
  • Molecular Weight 233.49
  • Synonym(s) 3-Bromo-5-chlorophenylethanone
  • SMILES CC(=O)C1=CC(Br)=CC(Cl)=C1

Description

1-(3-Bromo-5-chlorophenyl)ethanone features a brominated and chlorinated aromatic ring fused to a ketone-bearing ethyl side chain. This electron-deficient aryl ketone integrates readily into cross-coupling reactions, offering stable intermediates under standard conditions. The dual halogenation enables selective functionalization in synthetic pathways requiring orthogonal reactivity.

Application

1-(3-Bromo-5-chlorophenyl)ethanone serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of biaryl scaffolds via palladium-catalyzed cross-coupling reactions. The molecule’s bromo and chloro substituents provide orthogonal reactivity for sequential functionalization, while the ketone group facilitates nucleophilic addition and enolization. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step syntheses requiring selective transformation.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.3051
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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