2-Ethynylpyrazine

Name: 2-Ethynylpyrazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 153800-11-4
Cat. No. CS-0044099
Purity≥98%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 153800-11-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 153800-11-4
Cat. No. CS-0044099
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄N₂
Molecular Weight 104.11
Synonym(s) None
SMILES C#CC1=NC=CN=C1

Description

2-Ethynylpyrazine is a bench-stable, moisture-tolerant heteroaromatic building block featuring a terminal alkyne group at the 2-position of the pyrazine ring. This configuration enables efficient copper-catalyzed coupling reactions, facilitating rapid access to functionalized pyrazine derivatives for medicinal chemistry and materials science applications.

Application

2-Ethynylpyrazine serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed coupling reactions such as Sonogashira and Suzuki-Miyaura transformations. Its pyrazine core provides enhanced stability and favorable electronic properties for constructing heterocyclic frameworks. The terminal alkyne functionality offers high reactivity and compatibility with a range of functional groups, facilitating efficient access to complex scaffolds in medicinal chemistry and materials science applications.

Synthesis

Route1
- 904694-67-3
- ~51%
- In-stock
  
  153800-11-4
References
- Ube Industries, Ltd. Patent: EP1847545 A1, 2007 ; Location in patent: Page/Page column 54 ;
Route2
- 291763-66-1
- ~%
- In-stock
  
  153800-11-4
References
- Desai, Bimbisar; Dixon, Karen; Farrant, Elizabeth; Feng, Qixing; Gibson, Karl R.; Van Hoorn, Willem P.; Mills, James; Morgan, Trevor; Parry, David M.; Ramjee, Manoj K.; Selway, Christopher N.; Tarver, Gary J.; Whitlock, Gavin; Wright, Adrian G. Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3033 - 3047

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 25.78
LogP 0.4579
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Alkyne

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Key Words

2-Ethynylpyrazine sigma2-Ethynylpyrazine manufacturer2-Ethynylpyrazine price2-Ethynylpyrazine structure2-Ethynylpyrazine SDSbuy 2-Ethynylpyrazine2-Ethynylpyrazine supplier2-Ethynylpyrazine uses2-Ethynylpyrazine molecular weightprice of 2-Ethynylpyrazine2-Ethynylpyrazine chemical name formula of 2-Ethynylpyrazine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2-Ethynylpyrazine

CAS No. 153800-11-4

Recommended Products