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5-Bromo-3-(tert-butyl)-2-hydroxybenzaldehyde

  • CAS No. 153759-58-1

  • Cat. No. CS-0132177
  • Purity≥98%
  • MDL No.MFCD00456060
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-(tert-butyl)-2-hydroxybenzaldehyde|CS-0132177

Structure of 153759-58-1

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Description

5-Bromo-3-(tert-butyl)-2-hydroxybenzaldehyde features a sterically shielded tert-butyl group and a phenolic hydroxyl, enhancing stability and solubility in organic media. The bromine substituent enables facile cross-coupling reactions, while the aldehyde function serves as a direct handle for imine formation or reductive amination. This combination delivers a robust scaffold for synthesizing bioactive heterocycles and functionalized aromatics under standard conditions.

Application

5-Bromo-3-(tert-butyl)-2-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry and materials synthesis, enabling efficient access to substituted benzene scaffolds. The ortho-hydroxy and aldehyde functionalities facilitate cyclizations and metal-catalyzed coupling reactions, while the sterically hindered tert-butyl group enhances stability and aids in purification. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for multi-step synthesis and process development.

General Information

  • CAS No. 153759-58-1
  • Cat. No. CS-0132177
  • Purity ≥98%
  • MDL No. MFCD00456060
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃BrO₂
  • Molecular Weight 257.12
  • Synonym(s) 5-bromo-3-tert-butyl-2-hydroxybenzaldehyde
  • SMILES O=CC1=CC(Br)=CC(C(C)(C)C)=C1O

Computational Chemistry Data

  • TPSA   37.3
  • LogP   3.2647
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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