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Structure of 153034-80-1
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2-Fluoro-4-iodo-3-picoline is a fluorinated heteroaryl building block featuring complementary halogen handles for cross-coupling. The electron-deficient pyridine core enables efficient palladium-catalyzed reactions, while the ortho-fluorine enhances regioselectivity and metabolic stability. This bench-stable reagent integrates readily into complex molecular architectures.
2-Fluoro-4-iodo-3-picoline serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of substituted heterocycles and biaryl scaffolds. The ortho-fluoro substituent enhances reactivity in nucleophilic aromatic substitution, while the iodine group provides high compatibility with Suzuki, Stille, and Negishi coupling protocols. Bench-stable and readily purified by distillation, it functions effectively in multi-step syntheses requiring functional group tolerance and predictable regiochemistry.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: