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CS-W001157 4
Total: USD 88.00

Trimethyl(phenoxy)silane

  • CAS No. 1529-17-5

  • Cat. No. CS-0006241
  • Purity≥98%
  • MDL No.MFCD00053666

*For research and further manufacturing use only, not for direct human use.

Trimethyl(phenoxy)silane|CS-0006241

Structure of 1529-17-5

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General Information

  • CAS No. 1529-17-5
  • Cat. No. CS-0006241
  • Purity ≥98%
  • MDL No. MFCD00053666
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄OSi
  • Molecular Weight None
  • Synonym(s) Silane, trimethylphenoxy-
  • SMILES C[Si](C)(OC1=CC=CC=C1)C

Description

Trimethyl(phenoxy)silane features a phenyl ether group attached to a silicon center, delivering enhanced hydrolytic stability and improved compatibility with organosilane coupling agents. This bench-stable reagent integrates readily into surface functionalization protocols, offering efficient siloxane bridge formation under mild conditions.

Application

Trimethyl(phenoxy)silane serves as a stable, bench-ready silylating agent that facilitates efficient protection of alcohols and phenols. Its low volatility and ease of handling enable reliable functional group modulation in complex synthesis. The trimethylsilyl moiety provides robust protection under standard conditions, with straightforward deprotection using mild fluoride sources. Functions effectively in orthogonal protection strategies and supports scalable transformations in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      999-97-3
    • null|null
      108-95-2
    • ~99%
    • In-stock
      Trimethyl(phenoxy)silane|CS-0006241
      1529-17-5

    References

    • Shirini, Farhad; Khaligh, Nader Ghaffari; Akbari-Dadamahaleh, Somayeh Journal of Molecular Catalysis A: Chemical, 2012 , vol. 365, p. 15 - 23
  • Route2
    • null|null
      75-77-4
    • null|null
      108-95-2
    • ~96%
    • In-stock
      Trimethyl(phenoxy)silane|CS-0006241
      1529-17-5

    References

    • Abri, Abdolreza; Assadi, Mohammad Galeh; Pourreza, Samira Journal of the Chinese Chemical Society, 2012 , vol. 59, # 11 p. 1449 - 1454
  • Route3
    • In-stock
      Allyltrimethylsilane|CS-0031619
      762-72-1
    • null|null
      108-95-2
    • ~93%
    • In-stock
      Trimethyl(phenoxy)silane|CS-0006241
      1529-17-5

    References

    • Olah, George A.; Husain, Altaf; Gupta, B. C. Balaram; Salem, George F.; Narang, Subhash C. Journal of Organic Chemistry, 1981 , vol. 46, p. 5212 - 5214

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.9003
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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