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CS-W001157 4
Total: USD 88.00

1-(4-Bromo-3,5-difluorophenyl)ethanone

  • CAS No. 1528607-78-4

  • Cat. No. CS-0187926
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Bromo-3,5-difluorophenyl)ethanone|CS-0187926

Structure of 1528607-78-4

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General Information

  • CAS No. 1528607-78-4
  • Cat. No. CS-0187926
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrF₂O
  • Molecular Weight 235.03
  • Synonym(s) None
  • SMILES CC(=O)C1=CC(=C(C(=C1)F)Br)F

Description

This brominated aryl ketone features a sterically accessible carbonyl group flanked by electron-withdrawing fluorine atoms, enabling efficient coupling in cross-coupling reactions. The para-bromo substituent serves as a reactive handle for palladium-catalyzed transformations, while the difluorophenyl core enhances metabolic stability and lipophilicity in medicinal chemistry applications.

Application

1-(4-Bromo-3,5-difluorophenyl)ethanone serves as a versatile building block in medicinal chemistry and materials science, enabling efficient construction of complex aryl ketones. Its bromine and difluoro substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and enhanced metabolic stability in bioactive scaffolds. The compound exhibits excellent bench stability, facilitates straightforward purification via recrystallization, and functions reliably in standard coupling and functionalization protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.9299
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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