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CS-W001157 4
Total: USD 88.00

Ethyl 4-bromothiazole-5-carboxylate

  • CAS No. 152300-60-2

  • Cat. No. CS-W004509
  • Purity≥98%
  • MDL No.MFCD09909677

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-bromothiazole-5-carboxylate|CS-W004509

Structure of 152300-60-2

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General Information

  • CAS No. 152300-60-2
  • Cat. No. CS-W004509
  • Purity ≥98%
  • MDL No. MFCD09909677
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO₂S
  • Molecular Weight 236.09
  • Synonym(s) 5-Thiazolecarboxylicacid,4-bromo-,ethylester
  • SMILES CCOC(C1=C(N=CS1)Br)=O

Description

Ethyl 4-bromothiazole-5-carboxylate features a brominated thiazole core that enables direct functionalization in cross-coupling reactions. The ester group provides solubility in common organic solvents and serves as a handle for downstream derivatization. This bench-stable reagent integrates readily into synthetic sequences requiring heterocyclic building blocks with orthogonal reactivity.

Application

Ethyl 4-bromothiazole-5-carboxylate serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-established bromo-substitution at the 4-position. The ester group offers compatibility with standard hydrolysis and derivatization protocols, while the thiazole core provides robust stability and favorable electronic properties for further functionalization. Its bench-stable nature and predictable reactivity make it ideal for modular scaffold construction in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H317-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.0823
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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