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CS-W001157 4
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Methyl 4-bromothiazole-5-carboxylate

  • CAS No. 1353100-73-8

  • Cat. No. CS-0193289
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 4-bromothiazole-5-carboxylate|CS-0193289

Structure of 1353100-73-8

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General Information

  • CAS No. 1353100-73-8
  • Cat. No. CS-0193289
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄BrNO₂S
  • Molecular Weight 222.06
  • Synonym(s) methyl 4-bromo-1,3-thiazole-5-carboxylate
  • SMILES O=C(C1=C(Br)N=CS1)OC

Description

Methyl 4-bromothiazole-5-carboxylate features a brominated thiazole core with a methyl ester at the C5 position, enabling direct incorporation into heterocyclic scaffolds. This bench-stable reagent facilitates efficient cross-coupling and functionalization reactions in medicinal chemistry and materials synthesis.

Application

Methyl 4-bromothiazole-5-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its bromine substituent. The thiazole core provides metabolic stability and structural rigidity, while the ester group offers compatibility with standard functional group manipulations. This compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6922
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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