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3-Pyridin-2-ylpropanoic acid

  • CAS No. 15197-75-8

  • Cat. No. CS-0060616
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Pyridin-2-ylpropanoic acid|CS-0060616

Structure of 15197-75-8

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General Information

  • CAS No. 15197-75-8
  • Cat. No. CS-0060616
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₂
  • Molecular Weight 151.16
  • Synonym(s) 3-pyridin-2-yl-propanoic acid
  • SMILES C1=CC=NC(=C1)CCC(=O)O

Description

3-Pyridin-2-ylpropanoic acid features a pyridyl ring linked to a propanoic acid side chain, enabling integration into bioactive molecules requiring heterocyclic scaffolds. The carboxylic acid group facilitates conjugation and derivatization under standard conditions. This compound exhibits enhanced solubility in polar solvents and stability under ambient handling. It serves as a key intermediate for pharmaceuticals and functional materials where nitrogen-containing aromatic systems are essential.

Application

3-Pyridin-2-ylpropanoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its pyridine moiety provides enhanced solubility and metabolic stability, while the propionic acid side chain facilitates direct amidation, esterification, or decarboxylation under mild conditions. The compound exhibits excellent bench stability and is compatible with common purification methods, making it well-suited for high-throughput synthesis and process-scale applications.

Synthesis

  • Route1
    • null|null
      2859-68-9
    • ~77%
    • In-stock
      3-Pyridin-2-ylpropanoic acid|CS-0060616
      15197-75-8

    References

    • Abbott Laboratories Patent: US6162927 A1, 2000 ; US 6162927 A
  • Route2

    References

    • US5378840 A1, ; US 5378840 A
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 36, # 3 p. 320 - 330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H317-H318-H335
Precautionary Statements : P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.0988
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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