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(2-Chloro-6-(difluoromethoxy)phenyl)methanamine

  • CAS No. 1515925-06-0

  • Cat. No. CS-0102654
  • Purity≥96%
  • MDL No.MFCD23841190

*For research and further manufacturing use only, not for direct human use.

(2-Chloro-6-(difluoromethoxy)phenyl)methanamine|CS-0102654

Structure of 1515925-06-0

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General Information

  • CAS No. 1515925-06-0
  • Cat. No. CS-0102654
  • Purity ≥96%
  • MDL No. MFCD23841190
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClF₂NO
  • Molecular Weight 207.61
  • Synonym(s) 2-Chloro-6-(difluoroMethoxy)benzyl aMine
  • SMILES NCC1=C(OC(F)F)C=CC=C1Cl

Description

This bench-stable arylamine features a difluoromethoxy group that enhances metabolic stability and modulates electronic properties. The ortho-chlorine substituent introduces steric and electronic influence, enabling precise tuning in medicinal chemistry applications. This scaffold integrates readily into bioactive molecules for drug discovery workflows.

Application

(2-Chloro-6-(difluoromethoxy)phenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical scaffolds. Its ortho-chloro and difluoromethoxy substituents provide enhanced metabolic stability and modulated lipophilicity. The primary amine functionality facilitates straightforward derivatization via amidation, alkylation, or reductive amination, supporting efficient route development for targeted compound libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   2.4001
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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