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Structure of 125483-00-3
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3-Amino-4-(trifluoromethyl)benzoic acid features a strategically positioned trifluoromethyl group that enhances metabolic stability and lipophilicity, while the amino and carboxylic acid functionalities enable direct conjugation or salt formation. This scaffold integrates readily into bioactive molecules requiring electron-deficient aromatic cores and polar handles for solubility and derivatization under standard conditions.
3-Amino-4-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its dual functionality—amine and carboxylic acid—facilitates efficient coupling reactions, including amide formation and cyclization pathways. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the amino group provides a handle for derivatization under standard conditions. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring orthogonal reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: