Biotin-C4-amide-C5-NH2

Name: Biotin-C4-amide-C5-NH2
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CAS No. 151294-96-1
Cat. No. CS-0147804
Purity≥95%
MDL No.MFCD28397129

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 151294-96-1

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General Information

CAS No. 151294-96-1
Cat. No. CS-0147804
Purity ≥95%
MDL No. MFCD28397129
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₆N₄O₂S
Molecular Weight 314.45
Synonym(s) None
SMILES NCCCCNC(CCCC[C@@H]1SCC([H])([C@@]1(N2)[H])NC2=O)=O

Description

Biotin-C4-amide-C5-NH2 features a C4 amide linker and C5 amine terminus, enabling site-specific conjugation in bioconjugation workflows. This derivative combines biotin’s high-affinity binding with enhanced solubility and synthetic flexibility, facilitating efficient immobilization on solid supports or coupling to biomolecules under standard conditions.

Application

Biotin-C4-amide-C5-NH2 serves as a versatile bifunctional linker for bioconjugation and affinity purification. The C4-amide spacer enhances solubility and reduces steric hindrance, while the terminal primary amine enables facile coupling to carboxylated biomolecules or solid supports. This derivative facilitates efficient immobilization of biotinylated compounds in pull-down assays, enzyme labeling, and targeted delivery systems, offering robust stability and high binding affinity to streptavidin.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 96.25
LogP 0.5673
H_Acceptors 4
H_Donors 4
Rotatable_Bonds 9

Other Classifications

Life Science Linker Non-PEG linker

Life Science ADC Related Compound Cleavable Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Biotin-C4-amide-C5-NH2

CAS No. 151294-96-1

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