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1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde

  • CAS No. 1511782-19-6

  • Cat. No. CS-0052465
  • Molecule weight161.16
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde|CS-0052465

Structure of 1511782-19-6

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General Information

  • CAS No. 1511782-19-6
  • Cat. No. CS-0052465
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N₃O
  • Molecular Weight 161.16
  • Synonym(s) None
  • SMILES O=CC1=NN(C)C2=NC=CC=C21

Description

1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde features a fused heterocyclic core with a methylated pyrazole and a pyridine ring, delivering enhanced electronic density at the aromatic system. The aldehyde group enables direct coupling in multicomponent reactions, while the overall structure exhibits bench-stable behavior under standard conditions. This scaffold serves as a key building block for bioactive molecule synthesis.

Application

1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carbaldehyde serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of fused pyrazolo-pyridine scaffolds. The aldehyde functionality facilitates nucleophilic additions, reductive aminations, and imine formation under standard conditions. Bench-stable and compatible with common protecting group strategies, it supports scalable transformations in medicinal chemistry campaigns targeting kinase inhibitors and CNS-directed therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   47.78
  • LogP   0.7808
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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