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1-(2-Bromophenyl)cyclobutane-1-carboxylic acid

  • CAS No. 151157-44-7

  • Cat. No. CS-0101610
  • Purity≥98%
  • MDL No.MFCD11037044

*For research and further manufacturing use only, not for direct human use.

1-(2-Bromophenyl)cyclobutane-1-carboxylic acid|CS-0101610

Structure of 151157-44-7

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General Information

  • CAS No. 151157-44-7
  • Cat. No. CS-0101610
  • Purity ≥98%
  • MDL No. MFCD11037044
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁BrO₂
  • Molecular Weight 255.11
  • Synonym(s) 1-(2-BROMOPHENYL)CYCLOBUTANECARBOXYLIC ACID
  • SMILES O=C(C1(C2=CC=CC=C2Br)CCC1)O

Description

This cyclobutane carboxylic acid derivative features a 2-bromophenyl group directly attached to the cyclobutane ring, delivering a rigid, electron-deficient aromatic moiety. The carboxylic acid functionality enables direct coupling or derivatization in synthetic workflows. The molecule exhibits enhanced stability and solubility under standard conditions, facilitating use in medicinal chemistry and materials synthesis.

Application

1-(2-Bromophenyl)cyclobutane-1-carboxylic acid serves as a versatile building block for medicinal chemistry and synthetic organic applications. The cyclobutane core provides conformational rigidity, while the ortho-bromophenyl moiety enables palladium-catalyzed cross-coupling reactions. Its carboxylic acid functionality facilitates derivatization via esterification, amide formation, or activation for peptide coupling. The compound exhibits good bench stability and is compatible with standard purification techniques, making it suitable for iterative synthesis and scaffold diversification in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.9554
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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