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tert-Butyl 4-hydroxy-2,2-dimethylpiperidine-1-carboxylate

  • CAS No. 1502162-73-3

  • Cat. No. CS-0048214
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-hydroxy-2,2-dimethylpiperidine-1-carboxylate|CS-0048214

Structure of 1502162-73-3

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General Information

  • CAS No. 1502162-73-3
  • Cat. No. CS-0048214
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃NO₃
  • Molecular Weight 229.32
  • Synonym(s) 1-Piperidinecarboxylic acid, 4-hydroxy-2,2-dimethyl-, 1,1-dimethylethyl ester
  • SMILES CC(C)(C)OC(=O)N1CCC(O)CC1(C)C

Description

tert-Butyl 4-hydroxy-2,2-dimethylpiperidine-1-carboxylate features a sterically hindered piperidine core with a bench-stable hydroxyl group and a protecting tert-butyl ester. This combination enables selective derivatization in complex synthesis, particularly in medicinal chemistry applications where stability and controlled reactivity are essential.

Application

tert-Butyl 4-hydroxy-2,2-dimethylpiperidine-1-carboxylate serves as a versatile scaffold for the synthesis of functionalized piperidines, enabling efficient access to biologically relevant heterocycles. The protected hydroxyl group offers orthogonal reactivity in multi-step sequences, while the tert-butyl carbamate facilitates mild deprotection under acidic conditions. Its bench-stable nature and compatibility with diverse transformations make it ideal for medicinal chemistry campaigns requiring robust, scalable intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.1568
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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