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CS-W001157 4
Total: USD 88.00

1-Boc-3-((Methylamino)methyl)azetidine

  • CAS No. 1049730-81-5

  • Cat. No. CS-0045524
  • Purity≥98%
  • MDL No.MFCD08061965

*For research and further manufacturing use only, not for direct human use.

1-Boc-3-((Methylamino)methyl)azetidine|CS-0045524

Structure of 1049730-81-5

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General Information

  • CAS No. 1049730-81-5
  • Cat. No. CS-0045524
  • Purity ≥98%
  • MDL No. MFCD08061965
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₂
  • Molecular Weight 200.28
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC(CNC)C1

Description

1-Boc-3-((Methylamino)methyl)azetidine features a sterically hindered azetidine core with a methylamino-methyl side chain, enabling efficient incorporation into bioactive scaffolds. The Boc group provides stability during synthesis and facilitates selective deprotection under mild acidic conditions. This compound serves as a key building block for medicinal chemistry applications requiring nitrogen-rich heterocycles with tunable basicity and solubility.

Application

1-Boc-3-((methylamino)methyl)azetidine serves as a versatile building block for constructing nitrogen-containing heterocycles, particularly in medicinal chemistry and API development. The Boc-protected amine enables stable handling and selective deprotection under mild acidic conditions, while the pendant (methylamino)methyl group offers a reactive site for further functionalization. Its compatibility with standard coupling reactions and robust bench stability facilitate efficient synthesis of complex scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.0727
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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