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5-Cyclohexyl hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamate

  • CAS No. 150047-85-1

  • Cat. No. CS-0208242
  • Purity≥98%
  • MDL No.MFCD00270538

*For research and further manufacturing use only, not for direct human use.

5-Cyclohexyl hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamate|CS-0208242

Structure of 150047-85-1

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General Information

  • CAS No. 150047-85-1
  • Cat. No. CS-0208242
  • Purity ≥98%
  • MDL No. MFCD00270538
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₂₉NO₆
  • Molecular Weight 451.51
  • Synonym(s) Fmoc-Glu(OcHx)-OH
  • SMILES O=C(CC[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C(O)=O)OC4CCCCC4

Description

This fluorenylmethoxycarbonyl-protected glutamate derivative features a cyclohexyl group at the 5-position, enhancing hydrophobicity and steric bulk. The C-terminal carbamate linkage enables efficient coupling in peptide synthesis, while the fluorenylmethoxycarbonyl (Fmoc) moiety provides orthogonal protection for amine-directed strategies. This robust scaffold supports high-yield chain elongation under standard conditions.

Application

5-Cyclohexyl hydrogen N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamate serves as a robust, bench-stable amino acid derivative enabling efficient peptide coupling and protecting group manipulation in synthetic workflows. The Fmoc group ensures orthogonal protection during solid-phase synthesis, while the cyclohexyl side chain provides steric bulk and enhanced solubility. This derivative facilitates reliable amide bond formation and is compatible with standard deprotection and purification protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   4.6344
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   8

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