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CS-W001157 4
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2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

  • CAS No. 149353-95-7

  • Cat. No. CS-W006223
  • Purity≥98%
  • MDL No.MFCD03094736

*For research and further manufacturing use only, not for direct human use.

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid|CS-W006223

Structure of 149353-95-7

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General Information

  • CAS No. 149353-95-7
  • Cat. No. CS-W006223
  • Purity ≥98%
  • MDL No. MFCD03094736
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₉NO₄
  • Molecular Weight 277.32
  • Synonym(s) N-BOC-7-HYDROXYCARBONYL-1,2,3,4-TETRAHYDROISOQUINOLINE
  • SMILES O=C(C1=CC2=C(C=C1)CCN(C(OC(C)(C)C)=O)C2)O

Description

This tetrahydroisoquinoline derivative features a protected amine and carboxylic acid group, enabling direct incorporation into peptide synthesis. The tert-butoxycarbonyl moiety ensures stability during reaction sequences, while the electron-rich aromatic core supports efficient coupling under standard conditions.

Application

2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid serves as a versatile building block for the synthesis of isoquinoline-based scaffolds in medicinal chemistry. The tert-butyl ester group enables orthogonal protection and convenient deprotection under mild acidic conditions, while the carboxylic acid functionality supports direct coupling reactions. Its stability and compatibility with standard peptide and heterocyclic coupling protocols make it ideal for iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.678
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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