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CS-W001157 4
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4-Piperidin-4-ylbenzoic acid;hydrochloride

  • CAS No. 149353-84-4

  • Cat. No. CS-0060222
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Piperidin-4-ylbenzoic acid;hydrochloride|CS-0060222

Structure of 149353-84-4

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General Information

  • CAS No. 149353-84-4
  • Cat. No. CS-0060222
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆ClNO₂
  • Molecular Weight 241.71
  • Synonym(s) 4-(Piperidin-4-YL)benzoic acid hydrochloride
  • SMILES C1=C(C=CC(=C1)C(=O)O)C2CCNCC2.Cl

Description

4-Piperidin-4-ylbenzoic acid hydrochloride features a rigid aromatic core linked to a piperidine moiety, delivering enhanced solubility and metabolic stability. This zwitterionic structure facilitates efficient integration into bioactive scaffolds, particularly in kinase inhibitors and CNS-targeted pharmaceuticals. The hydrochloride salt ensures excellent crystallinity and handling under standard bench conditions.

Application

4-Piperidin-4-ylbenzoic acid hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard amide coupling and functional group interconversions. The piperidine moiety provides a basic nitrogen for salt formation and enhanced solubility, while the carboxylic acid facilitates conjugation with peptides, heterocycles, and other pharmacophores. Its bench-stable hydrochloride salt form simplifies handling and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   2.2736
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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