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CS-W001157 4
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5-(Pyridin-3-yl)-1H-pyrazol-3-amine

  • CAS No. 149246-87-7

  • Cat. No. CS-0156825
  • Molecule weight160.18
  • Purity≥95%
  • MDL No.MFCD11107433

*For research and further manufacturing use only, not for direct human use.

5-(Pyridin-3-yl)-1H-pyrazol-3-amine|CS-0156825

Structure of 149246-87-7

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General Information

  • CAS No. 149246-87-7
  • Cat. No. CS-0156825
  • Purity ≥95%
  • MDL No. MFCD11107433
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₄
  • Molecular Weight 160.18
  • Synonym(s) 5-Pyridin-3-YL-2H-pyrazol-3-ylamine
  • SMILES NC1=NNC(C2=CC=CN=C2)=C1

Description

5-(Pyridin-3-yl)-1H-pyrazol-3-amine features a fused pyrazole-pyridine scaffold with a strategically positioned primary amine, enabling direct conjugation in synthetic routes. This electron-rich heterocycle integrates readily into bioactive molecules, offering enhanced solubility and metabolic stability in pharmaceutical development workflows.

Application

5-(Pyridin-3-yl)-1H-pyrazol-3-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to biologically relevant scaffolds. Its pyrazole core exhibits robust bench stability and tolerates a range of functional groups, facilitating downstream derivatization via coupling reactions, electrophilic substitution, or transition-metal-catalyzed transformations. The molecule functions effectively in the construction of kinase inhibitors and other targeted therapeutics, offering predictable reactivity and ease of purification in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      287493-97-4
    • ~74%
    • In-stock
      5-(Pyridin-3-yl)-1H-pyrazol-3-amine|CS-0156825
      149246-87-7

    References

    • Chang, Kwan Young; Kim, Sung Hoon; Nam, Ghilsoo; Seo, Jae Hong; Kim, Joong Hyup; Ha, Deok-Chan Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1211 - 1214
  • Route2
    • null|null
      100-54-9
    • ~%
    • In-stock
      5-(Pyridin-3-yl)-1H-pyrazol-3-amine|CS-0156825
      149246-87-7

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 11 p. 1211 - 1214
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 3 p. 922 - 926

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   67.59
  • LogP   1.0539
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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