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CS-W001157 4
Total: USD 88.00

1-(4-Aminophenyl)propan-1-one

  • CAS No. 70-69-9

  • Cat. No. CS-0152655
  • Purity≥98%
  • MDL No.MFCD00017113

*For research and further manufacturing use only, not for direct human use.

1-(4-Aminophenyl)propan-1-one|CS-0152655

Structure of 70-69-9

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General Information

  • CAS No. 70-69-9
  • Cat. No. CS-0152655
  • Purity ≥98%
  • MDL No. MFCD00017113
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO
  • Molecular Weight 149.19
  • Synonym(s) para-Aminopropiophenone
  • SMILES CCC(=O)C1=CC=C(C=C1)N

Description

1-(4-Aminophenyl)propan-1-one features a para-aminoaryl group linked to a ketone-bearing propyl chain, enabling integration into conjugated systems. This electron-rich scaffold facilitates coupling reactions and serves as a key intermediate in pharmaceutical synthesis. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions.

Application

1-(4-Aminophenyl)propan-1-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of diverse aryl ketone derivatives through standard coupling and functionalization reactions. Its aniline functionality offers enhanced reactivity in amide formation, electrophilic substitution, and transition-metal-catalyzed transformations. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development and heterocyclic scaffold construction.

Synthesis

  • Route1
    • null|null
      10342-83-3
    • ~94%
    • In-stock
      1-(4-Aminophenyl)propan-1-one|CS-0152655
      70-69-9

    References

    • Lee, Dae-Yon; Hartwig, John F. Organic Letters, 2005 , vol. 7, # 6 p. 1169 - 1172
  • Route2
    • null|null
      1040063-44-2
    • ~79%
    • In-stock
      1-(4-Aminophenyl)propan-1-one|CS-0152655
      70-69-9

    References

    • Yu, Jianzhong; Zhang, Peizhi; Wu, Jun; Shang, Zhicai Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3167 - 3170
  • Route3
    • null|null
      67-56-1
    • p-Nitrophenyl methyl ketone Clenbuterol  Impurity|CS-0229063
      100-19-6
    • ~85%
    • In-stock
      1-(4-Aminophenyl)propan-1-one|CS-0152655
      70-69-9
    • 1-(4-Aminophenyl)ethanone Clenbuterol Impurity|CS-0229065
      99-92-3

    References

    • Tetrahedron Letters, , vol. 54, # 45 p. 6094 - 6096

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.8615
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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