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CS-W001157 4
Total: USD 88.00

4-bromo-3-methyl-Benzenemethanamine

  • CAS No. 149104-92-7

  • Cat. No. CS-0022318
  • Purity≥95%
  • MDL No.MFCD06213254

*For research and further manufacturing use only, not for direct human use.

4-bromo-3-methyl-Benzenemethanamine|CS-0022318

Structure of 149104-92-7

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General Information

  • CAS No. 149104-92-7
  • Cat. No. CS-0022318
  • Purity ≥95%
  • MDL No. MFCD06213254
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀BrN
  • Molecular Weight 200.08
  • Synonym(s) (4-Bromo-3-methylphenyl)methanamine
  • SMILES NCC1=CC=C(Br)C(C)=C1

Description

4-Bromo-3-methyl-Benzenemethanamine features a brominated aromatic ring with methyl and methanamine substituents in a strategic ortho relationship, enabling direct integration into pharmaceutical scaffolds. The amine group facilitates coupling reactions under standard conditions, while the electron-withdrawing bromine enhances regioselectivity in cross-coupling processes. This compound serves as a key intermediate for bioactive molecule synthesis.

Application

4-Bromo-3-methylbenzenemethanamine serves as a versatile arylamine building block for pharmaceutical and agrochemical synthesis. Its bromo and methyl substituents enable sequential functionalization via palladium-catalyzed cross-coupling and electrophilic substitution, while the primary amine facilitates derivatization through acylation, alkylation, or imine formation. The compound exhibits good bench stability and is compatible with common protecting group strategies, supporting efficient access to substituted benzene scaffolds in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H312-H315-H318-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.21622
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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