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CS-W001157 4
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(5-Fluoro-2-methoxyphenyl)methanamine

  • CAS No. 148870-38-6

  • Cat. No. CS-0447041
  • Purity≥96%
  • MDL No.MFCD06213625

*For research and further manufacturing use only, not for direct human use.

(5-Fluoro-2-methoxyphenyl)methanamine|CS-0447041

Structure of 148870-38-6

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General Information

  • CAS No. 148870-38-6
  • Cat. No. CS-0447041
  • Purity ≥96%
  • MDL No. MFCD06213625
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀FNO
  • Molecular Weight 155.17
  • Synonym(s) 5-Fluoro-2-methoxybenzylamine
  • SMILES COC1=CC=C(C=C1CN)F

Description

(5-Fluoro-2-methoxyphenyl)methanamine features a fluorinated aromatic core with a methoxy group positioned ortho to the amino-methyl side chain, delivering enhanced metabolic stability and favorable lipophilicity. This scaffold integrates readily into bioactive molecules, particularly in medicinal chemistry projects targeting CNS agents and kinase inhibitors, where its electronic profile supports target engagement. The compound exhibits bench-stable handling characteristics and compatibility with standard coupling protocols.

Application

(5-Fluoro-2-methoxyphenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methoxy and meta-fluoro substituents provide enhanced metabolic stability and modulate electronic properties for target-directed design. The primary amine functionality facilitates straightforward coupling reactions, while the aromatic scaffold exhibits excellent bench stability and compatibility with standard purification methods.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.293
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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