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CS-W001157 4
Total: USD 88.00

6-(Chloromethyl)nicotinic acid

  • CAS No. 148258-27-9

  • Cat. No. CS-0447014
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(Chloromethyl)nicotinic acid|CS-0447014

Structure of 148258-27-9

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General Information

  • CAS No. 148258-27-9
  • Cat. No. CS-0447014
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 6-(chloromethyl)pyridine-3-carboxylic acid
  • SMILES C1=CC(=NC=C1C(=O)O)CCl

Description

6-(Chloromethyl)nicotinic acid features a reactive chloromethyl group positioned ortho to the carboxylic acid on a pyridine ring, enabling direct functionalization in synthetic transformations. This bifunctional architecture supports efficient conjugation strategies in medicinal chemistry and materials synthesis, where site-specific derivatization is required. The compound exhibits good stability under standard bench conditions and facilitates modular assembly of bioactive scaffolds.

Application

6-(Chloromethyl)nicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The chloromethyl group enables efficient nucleophilic substitution, while the carboxylic acid facilitates amide coupling or esterification, offering orthogonal functionalization in complex molecule assembly. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5186
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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