1-Bromo-2,4-dichloro-5-fluorobenzene

Name: 1-Bromo-2,4-dichloro-5-fluorobenzene
Brand: ChemScene
Availability: InStock
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CAS No. 1481-63-6
Cat. No. CS-0036607
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Bromo-2,4-dichloro-5-fluorobenzene|CS-0036607

Structure of 1481-63-6

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General Information

CAS No. 1481-63-6
Cat. No. CS-0036607
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrCl₂F
Molecular Weight 243.89
Synonym(s) 5-BroMo-2,4-dichlorofluorobenzene
SMILES C1=C(C(=CC(=C1F)Cl)Cl)Br

Description

1-Bromo-2,4-dichloro-5-fluorobenzene features a highly reactive aryl bromide positioned within a fluorinated, dichlorinated aromatic framework. This electron-deficient scaffold enables efficient cross-coupling transformations under mild conditions. The molecule exhibits enhanced stability and solubility in common organic solvents, facilitating its use in precision synthesis of pharmaceutical intermediates and functional materials.

Application

1-Bromo-2,4-dichloro-5-fluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromine center facilitates efficient Suzuki, Negishi, or Stille couplings, while the chloro and fluoro substituents provide enhanced metabolic stability and modulate electronic properties. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step synthetic sequences requiring selective functionalization.

Synthesis

Route1
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  1481-63-6
References
- Vorozhtsov,N.N. et al. J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, # 5 p. 1674 - 1678,1561 - 1564
Route2
- In-stock
  
  348-64-1
- ~%
- In-stock
  
  1481-63-6
References
- Vorozhtsov,N.N. et al. J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, # 5 p. 1674 - 1678,1561 - 1564

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 0
LogP 3.895
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-2,4-dichloro-5-fluorobenzene

CAS No. 1481-63-6

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