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CS-W001157 4
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4-Bromo-3-fluoro-N-(thiophen-2-ylmethyl)aniline

  • CAS No. 1480547-81-6

  • Cat. No. CS-0304544
  • Molecule weight286.16
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-3-fluoro-N-(thiophen-2-ylmethyl)aniline|CS-0304544

Structure of 1480547-81-6

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General Information

  • CAS No. 1480547-81-6
  • Cat. No. CS-0304544
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉BrFNS
  • Molecular Weight 286.16
  • Synonym(s) None
  • SMILES FC1=CC(NCC2=CC=CS2)=CC=C1Br

Description

4-Bromo-3-fluoro-N-(thiophen-2-ylmethyl)aniline features a strategically positioned bromo and fluoro substituent on the aromatic ring, enhancing electronic modulation and enabling selective coupling reactions. The thiophen-2-ylmethyl group provides a robust, electron-donating handle for further functionalization in cross-coupling and medicinal chemistry applications.

Application

4-Bromo-3-fluoro-N-(thiophen-2-ylmethyl)aniline serves as a versatile building block in medicinal chemistry, enabling the construction of biologically relevant heterocyclic scaffolds. Its ortho-halogenated aniline core facilitates palladium-catalyzed cross-coupling reactions, while the thiophene-containing amine functionality provides orthogonal reactivity and enhanced solubility. The molecule exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   4.2618
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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