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CS-W001157 4
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exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione

  • CAS No. 14805-29-9

  • Cat. No. CS-W003844
  • Purity≥97%
  • MDL No.MFCD12964181

*For research and further manufacturing use only, not for direct human use.

exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione|CS-W003844

Structure of 14805-29-9

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General Information

  • CAS No. 14805-29-9
  • Cat. No. CS-W003844
  • Purity ≥97%
  • MDL No. MFCD12964181
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) None
  • SMILES O=C(N1)[C@@]([C@]([H])(C2)CC[C@@]32[H])([H])[C@@]3([H])C1=O

Description

exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione features a rigid, polycyclic scaffold with high thermal stability and defined stereochemistry. This bench-stable, moisture-tolerant core integrates readily into complex molecular architectures, serving as a key building block in the synthesis of bioactive compounds and functional materials.

Application

exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione serves as a rigid, bicyclic scaffold for medicinal chemistry applications, offering defined stereochemistry and enhanced metabolic stability. Its fused ring system facilitates efficient functionalization at the 2- and 6-positions, enabling direct incorporation into complex heterocyclic frameworks. The compound exhibits excellent bench stability and compatibility with standard synthetic transformations, including nucleophilic substitution and transition-metal-catalyzed couplings. This makes it a practical building block for API development and library synthesis.

Synthesis

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    References

    • Ishizumi; Kojima; Antoku Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2288 - 2300 Title/Abstract Full Text View citing articles Show Details Ishizumi; Kojima; Antoku; Saji; Yoshigi Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 12 p. 2139 - 2151
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    References

    • Chemical and Pharmaceutical Bulletin, , vol. 43, # 12 p. 2139 - 2151
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    • In-stock
      exo-Hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione|CS-W003844
      14805-29-9

    References

    • WO2013/121440 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   0.3051
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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