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CS-W001157 4
Total: USD 88.00

4-(Methylsulfonyl)phenol

  • CAS No. 14763-60-1

  • Cat. No. CS-W004825
  • Purity≥98%
  • MDL No.MFCD00047806

*For research and further manufacturing use only, not for direct human use.

4-(Methylsulfonyl)phenol|CS-W004825

Structure of 14763-60-1

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General Information

  • CAS No. 14763-60-1
  • Cat. No. CS-W004825
  • Purity ≥98%
  • MDL No. MFCD00047806
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈O₃S
  • Molecular Weight 172.20
  • Synonym(s) P-(Methylsulfonyl)Phenol
  • SMILES C1=C([S](C)(=O)=O)C=CC(=C1)O

Description

4-(Methylsulfonyl)phenol features a phenolic hydroxyl group flanked by a strongly electron-withdrawing methylsulfonyl substituent at the para position. This combination imparts enhanced acidity and stability, enabling direct use in electrophilic substitution reactions and as a building block for functionalized aryl scaffolds in medicinal chemistry and materials science.

Application

4-(Methylsulfonyl)phenol serves as a versatile building block in medicinal chemistry and materials science, enabling the introduction of a polar, electron-withdrawing sulfone group at the para position of an aromatic ring. Its stability under standard reaction conditions facilitates downstream functionalization, including nucleophilic substitution and metal-catalyzed coupling reactions. The compound exhibits excellent solubility in common organic solvents and is readily purified by recrystallization or chromatography, making it well-suited for scalable synthesis and process development.

Synthesis

  • Route1

    References

    • Journal of Organic Chemistry, , vol. 68, # 13 p. 5388 - 5391
  • Route2

    References

    • WO2005/66131 A1, ; Page/Page column 103-104 ;
  • Route3

    References

    • Organic Letters, , vol. 9, # 17 p. 3405 - 3408

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.37
  • LogP   0.7957
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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