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CS-W001157 4
Total: USD 88.00

Ethyl (diethoxyphosphoryl)formate

  • CAS No. 1474-78-8

  • Cat. No. CS-0318513
  • Molecule weight210.16
  • Purity≥97%
  • MDL No.MFCD00009108

*For research and further manufacturing use only, not for direct human use.

Ethyl (diethoxyphosphoryl)formate|CS-0318513

Structure of 1474-78-8

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General Information

  • CAS No. 1474-78-8
  • Cat. No. CS-0318513
  • Purity ≥97%
  • MDL No. MFCD00009108
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅O₅P
  • Molecular Weight 210.16
  • Synonym(s) Triethyl Phosphonoformate
  • SMILES CCOC(=O)P(=O)(OCC)OCC

Description

Azidoacetic acid NHS ester is a simple azido-containing reagent with an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines at pH 7-9 forming a stable amide bond. The azide allows for chemoselective ligation with an alkyne or cyclooctyne. It is generally used to functionalize amines and amino acids with azidoacetyl groups. It is generally used in click chemistry applications.

Synthesis

  • Route1
    • null|null
      30410-95-8
    • ~82%
    • In-stock
      Ethyl (diethoxyphosphoryl)formate|CS-0318513
      1474-78-8

    References

    • Livantsov, M. V.; Proskurnina, M. V.; Prishchenko, A. A.; Lutsenko, I. F. J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 11 p. 2504 - 2517,2237 - 2249
  • Route2
    • null|null
      541-41-3
    • null|null
      122-52-1
    • ~89%
    • In-stock
      Ethyl (diethoxyphosphoryl)formate|CS-0318513
      1474-78-8

    References

    • Maeda, Hatsuo; Takahashi, Kenji; Ohmori, Hidenobu Tetrahedron, 1998 , vol. 54, # 40 p. 12233 - 12242
  • Route3
    • Diethyl (diethoxymethyl)phosphonate|CS-0582670
      17997-33-0
    • ~80%
    • In-stock
      Ethyl (diethoxyphosphoryl)formate|CS-0318513
      1474-78-8

    References

    • Rol'nik, L. Z.; Pastushenko, E. V.; Livantsov, M. V.; Proskurnina, M. V.; Zlot-skii, S. S.; Rakhmankulov, D. L. J. Gen. Chem. USSR (Engl. Transl.), 1983 , vol. 53, # 6 p. 1238 - 1242,1104 - 1109

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H317-H319-H335
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501-P260-P271-P304+P340-P312-P403+P233-P405

Quality Control

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Computational Chemistry Data

  • TPSA   61.83
  • LogP   2.409
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   6

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