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CS-W001157 4
Total: USD 88.00

5-Aminobenzo[d]oxazol-2(3H)-one

  • CAS No. 14733-77-8

  • Cat. No. CS-0131614
  • Purity≥97%
  • MDL No.MFCD00474884

*For research and further manufacturing use only, not for direct human use.

5-Aminobenzo[d]oxazol-2(3H)-one|CS-0131614

Structure of 14733-77-8

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General Information

  • CAS No. 14733-77-8
  • Cat. No. CS-0131614
  • Purity ≥97%
  • MDL No. MFCD00474884
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂O₂
  • Molecular Weight 150.13
  • Synonym(s) 5-Amino-2,3-dihydro-1,3-benzoxazol-2-one
  • SMILES O=C1OC2=CC=C(N)C=C2N1

Description

5-Aminobenzo[d]oxazol-2(3H)-one integrates a nucleophilic amine and a lactam carbonyl within a fused heteroaromatic framework, enabling direct functionalization in synthetic routes. This bench-stable scaffold supports rapid derivatization for bioactive molecule development.

Application

5-Aminobenzo[d]oxazol-2(3H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its dual amine and lactam functionalities offer orthogonal reactivity for derivatization, while the inherent stability supports straightforward purification and handling. The scaffold is well-suited for modular synthesis of kinase inhibitors and other targeted therapeutics via standard coupling protocols.

Synthesis

  • Route1

    References

    • AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara Patent: WO2012/59932 A1, 2012 ; Location in patent: Page/Page column 165 ; WO 2012/059932 A1
  • Route2
    • null|null
      99-57-0
    • ~%
    • In-stock
      5-Aminobenzo[d]oxazol-2(3H)-one|CS-0131614
      14733-77-8

    References

    • Journal of Pharmaceutical Sciences, , vol. 53, p. 538 - 544
  • Route3

    References

    • Journal of Pharmaceutical Sciences, , vol. 53, p. 538 - 544

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.02
  • LogP   0.7033
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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