Lot numbers can be found on the outside label of a product:
I-bu-rG Phosphoramidite
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CAS No. 147201-04-5
- Cat. No. CS-W006103
- Purity≥96%
- MDL No.MFCD00080299
*For research and further manufacturing use only, not for direct human use.
Structure of 147201-04-5
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General Information
- CAS No. 147201-04-5
- Cat. No. CS-W006103
- Purity ≥96%
- MDL No. MFCD00080299
- Storage -20°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅₀H₆₈N₇O₉PSi
- Molecular Weight 970.18
- Synonym(s) None
- SMILES COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N5C(N=C(NC(C(C)C)=O)NC6=O)=C6N=C5)O4
Description
Heptafluorobutyric anhydride is a perfluoroacylated acylation reagent, that forms stable, volatile derivatives with alcohols, amines, and phenols. It is majorly used to prepare electron-capturing derivatives for GC/electron capture detection. It is generally used with an acid scavenger, to help drive the reaction to completion and to prevent column damage from acidic by-products of the derivatization reaction. It is also used for the frequent testing of drugs of abuse such as, amphetamines and phencyclidine by GC-MS technique.Learn more in the Product Information
Application
I-bu-rG Phosphoramidite serves as a key building block for the synthesis of oligonucleotide sequences containing guanine derivatives, enabling efficient incorporation during solid-phase synthesis. Its sterically hindered isobutyl group enhances stability and reduces side reactions, while maintaining high coupling efficiency. The phosphoramidite functions reliably in standard DNA/RNA synthesis protocols, offering excellent yield and purity for research-scale applications.
Synthesis
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References
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Zhang, Zhaoying; Gaffney, Barbara L.; Jones, Roger A. Journal of the American Chemical Society, 2004 , vol. 126, # 51 p. 16700 - 16701
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Route2
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124482-92-4 -
In-stock
81279-39-2 - ~91%
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In-stock
147201-04-5
References
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Hardacre, Christopher; Huang, Haifeng; James, Stuart L.; Migaud, Marie E.; Norman, Sarah E.; Pitner, William R. Chemical Communications, 2011 , vol. 47, # 20 p. 5846 - 5848
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Route3
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108-18-9
- ~%
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In-stock
147201-04-5
References
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Chemical Communications, , vol. 47, # 20 p. 5846 - 5848
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 184.31
- LogP 9.68898
- H_Acceptors 14
- H_Donors 2
- Rotatable_Bonds 21
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Key Words
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