3'-TBDMS-ibu-rG Phosphoramidite

Name: 3'-TBDMS-ibu-rG Phosphoramidite
Brand: ChemScene
Availability: InStock
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CAS No. 1445905-51-0
Cat. No. CS-0158089
Purity≥97%
MDL No.MFCD30475539

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3'-TBDMS-ibu-rG Phosphoramidite|CS-0158089

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General Information

CAS No. 1445905-51-0
Cat. No. CS-0158089
Purity ≥97%
MDL No. MFCD30475539
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅₀H₆₈N₇O₉PSi
Molecular Weight 970.18
Synonym(s) None
SMILES COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N5C(N=C(NC(C(C)C)=O)NC6=O)=C6N=C5)O4

Description

3'-TBDMS-ibu-rG Phosphoramidite delivers a protected guanine building block with orthogonal functionality for solid-phase oligonucleotide synthesis. The TBDMS group at the 3' position provides robust protection against degradation, while the ibu (isobutyryl) moiety enhances stability and facilitates efficient coupling. This phosphoramidite integrates seamlessly into nucleic acid sequences under standard conditions, enabling precise incorporation of modified guanosine units in therapeutic and diagnostic applications.

Application

3'-TBDMS-ibu-rG phosphoramidite serves as a key building block for the synthesis of modified oligonucleotides, enabling site-specific incorporation of a 3'-O-(tert-butyldimethylsilyl)-protected inosine derivative. The TBDMS group provides robust protection during synthesis and facilitates selective deprotection under mild conditions. Its compatibility with standard solid-phase synthesis protocols and excellent stability make it ideal for constructing complex nucleic acid architectures requiring orthogonal functionalization.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 184.31
LogP 9.68898
H_Acceptors 14
H_Donors 2
Rotatable_Bonds 21

Other Classifications

Life Science Nucleosides & Nucleotides Nucleosides, Deoxyribonucleosides and Other Nucleosides

Catalysis Compounds by Element Classes Metal Compounds Semimetal Compounds

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

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3'-TBDMS-ibu-rG Phosphoramidite

CAS No. 1445905-51-0

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