1-Tert-Butyl 2-methyl pyrrolidine-1,2-dicarboxylate

Name: 1-Tert-Butyl 2-methyl pyrrolidine-1,2-dicarboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 145681-01-2
Cat. No. CS-0008676
Purity≥98%
MDL No.MFCD03762834

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Tert-Butyl 2-methyl pyrrolidine-1,2-dicarboxylate|CS-0008676

Structure of 145681-01-2

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Description

1-Tert-Butyl 2-methyl pyrrolidine-1,2-dicarboxylate features a sterically hindered pyrrolidine core with orthogonal ester handles, enabling selective deprotection and functionalization. The tert-butyl group provides exceptional stability under basic conditions, while the methyl substituent enhances regioselectivity in asymmetric synthesis. This robust scaffold facilitates efficient access to chiral intermediates for medicinal chemistry applications.

Application

1-Tert-Butyl 2-methyl pyrrolidine-1,2-dicarboxylate serves as a versatile chiral building block in synthetic organic chemistry, enabling efficient access to substituted pyrrolidines via selective deprotection and functionalization. The tert-butyl ester group offers excellent bench stability and facilitates straightforward purification, while the methyl substituent provides defined stereochemical control. It functions effectively in standard coupling reactions, cycloadditions, and transition-metal-catalyzed transformations, making it well-suited for medicinal chemistry and process development workflows.

General Information

CAS No. 145681-01-2
Cat. No. CS-0008676
Purity ≥98%
MDL No. MFCD03762834
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₉NO₄
Molecular Weight 229.27
Synonym(s) t-BOC-L-Pro-OMe
SMILES O=C(N1C(C(OC)=O)CCC1)OC(C)(C)C

Computational Chemistry Data

TPSA 55.84
LogP 1.5589
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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1-Tert-Butyl 2-methyl pyrrolidine-1,2-dicarboxylate

CAS No. 145681-01-2

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