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CS-W001157 4
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(2,6-Dichloro-4-methylphenyl)boronic acid

  • CAS No. 1451391-51-7

  • Cat. No. CS-0186038
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2,6-Dichloro-4-methylphenyl)boronic acid|CS-0186038

Structure of 1451391-51-7

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General Information

  • CAS No. 1451391-51-7
  • Cat. No. CS-0186038
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BCl₂O₂
  • Molecular Weight 204.85
  • Synonym(s) 2,6-Dichloro-4-methylphenylboronic acid
  • SMILES CC1=CC(=C(C(=C1)Cl)B(O)O)Cl

Description

This boronate moiety features a sterically hindered aryl core with electron-withdrawing chlorine substituents and a methyl group at the 4-position, enhancing stability and tuning reactivity. Designed for efficient Suzuki-Miyaura coupling, it delivers reliable cross-coupling under standard conditions with minimal protodeboronation.

Application

(2,6-Dichloro-4-methylphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-chlorine substituents enhance stability and facilitate downstream functionalization, while the methyl group provides steric and electronic tuning. The compound exhibits excellent bench stability, ease of purification, and broad functional group tolerance, making it well-suited for the synthesis of complex arylated scaffolds in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.98162
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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