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CS-W001157 4
Total: USD 88.00

tert-Butyl (3-amino-2-hydroxypropyl)carbamate

  • CAS No. 144912-84-5

  • Cat. No. CS-0037654
  • Purity≥95%
  • MDL No.MFCD04118107

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3-amino-2-hydroxypropyl)carbamate|CS-0037654

Structure of 144912-84-5

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General Information

  • CAS No. 144912-84-5
  • Cat. No. CS-0037654
  • Purity ≥95%
  • MDL No. MFCD04118107
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈N₂O₃
  • Molecular Weight None
  • Synonym(s) Tert-butyl n-(3-amino-2-hydroxypropyl)carbamate
  • SMILES CC(C)(C)OC(=O)NCC(CN)O

Description

tert-Butyl (3-amino-2-hydroxypropyl)carbamate features a bifunctional side chain bearing both a primary amine and a hydroxyl group, enabling selective derivatization in peptide synthesis. The tert-butyl carbamate moiety provides stable protection under standard conditions while permitting mild deprotection with acid. This combination supports efficient incorporation into complex molecular architectures.

Application

tert-Butyl (3-amino-2-hydroxypropyl)carbamate serves as a versatile bifunctional building block in synthetic organic chemistry, enabling the concurrent introduction of both amino and hydroxyl functionalities under mild conditions. The tert-butoxycarbonyl (Boc) group provides robust protection for the amine, allowing orthogonal deprotection in acidic or hydrogenolytic conditions. Its hydroxyl moiety supports derivatization via esterification or ether formation, while maintaining compatibility with standard coupling and functional group manipulation protocols. This stability and reactivity profile makes it particularly useful in peptide synthesis, carbohydrate chemistry, and the construction of complex heterocyclic scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H318-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   84.58
  • LogP   -0.1693
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   3

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