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CS-W001157 4
Total: USD 88.00

2-(Difluoromethyl)pyridin-4-amine

  • CAS No. 1446509-58-5

  • Cat. No. CS-0102111
  • Purity≥97%
  • MDL No.MFCD25476532

*For research and further manufacturing use only, not for direct human use.

2-(Difluoromethyl)pyridin-4-amine|CS-0102111

Structure of 1446509-58-5

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General Information

  • CAS No. 1446509-58-5
  • Cat. No. CS-0102111
  • Purity ≥97%
  • MDL No. MFCD25476532
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆F₂N₂
  • Molecular Weight 144.12
  • Synonym(s) 4-Amino-2-(difluoromethyl)pyridine
  • SMILES NC1=CC(C(F)F)=NC=C1

Description

2-(Difluoromethyl)pyridin-4-amine features a difluoromethyl group attached to a pyridine ring, delivering enhanced metabolic stability and modulated lipophilicity. This electron-deficient heterocycle integrates readily into medicinal chemistry campaigns, enabling direct incorporation into bioactive scaffolds through straightforward coupling reactions.

Application

2-(Difluoromethyl)pyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive scaffolds. The pyridine nitrogen and primary amine functionality offer orthogonal reactivity for downstream derivatization. It exhibits good bench stability and facilitates efficient coupling reactions, making it well-suited for the synthesis of kinase inhibitors and other targeted therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.6014
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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