H-Phe(3-CF3)-OH

Name: H-Phe(3-CF3)-OH
Brand: ChemScene
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CAS No. 14464-68-7
Cat. No. CS-0312896
Purity≥95%
MDL No.MFCD00044945

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

(S)-2-amino-3-(3-(trifluoromethyl)phenyl)propanoic acid is a chiral building block featuring a sterically hindered aryl trifluoromethyl group. This configuration enhances metabolic stability and bioavailability, making it valuable in peptide synthesis and medicinal chemistry. The molecule integrates readily into peptidomimetic scaffolds and supports the development of targeted therapeutics.

Application

(S)-2-Amino-3-(3-(trifluoromethyl)phenyl)propanoic acid serves as a valuable chiral building block for the synthesis of bioactive molecules, particularly in medicinal chemistry. Its trifluoromethyl-substituted aromatic ring enhances metabolic stability and membrane permeability. The molecule exhibits bench stability, tolerates common functional groups, and facilitates straightforward purification. It functions effectively in peptide coupling reactions and serves as a core scaffold for CNS-targeted compounds and kinase inhibitors.

General Information

CAS No. 14464-68-7
Cat. No. CS-0312896
Purity ≥95%
MDL No. MFCD00044945
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀F₃NO₂
Molecular Weight 233.19
Synonym(s) None
SMILES C([C@@H](C(O)=O)N)C1=CC(C(F)(F)F)=CC=C1

Computational Chemistry Data

TPSA 63.32
LogP 1.6598
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 3

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅰ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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H-Phe(3-CF3)-OH

CAS No. 14464-68-7

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