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Structure of 1445891-27-9
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8-Bromo-5-chloro-1,2,3,4-tetrahydroisoquinoline features a rigid, electron-deficient tetrahydroisoquinoline core bearing strategically positioned halogen substituents. This combination enables direct functionalization in cross-coupling reactions and provides enhanced metabolic stability for medicinal chemistry applications.
8-Bromo-5-chloro-1,2,3,4-tetrahydroisoquinoline serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its electron-deficient aromatic core enables directed metalation and cross-coupling reactions, while the bromo and chloro substituents offer orthogonal reactivity for sequential functionalization. Bench-stable and amenable to purification by standard chromatography, it facilitates the synthesis of complex isoquinoline-based scaffolds relevant to kinase inhibitors and CNS-targeted compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: