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CS-W001157 4
Total: USD 88.00

Dibromomaleimide-C5-COOH

  • CAS No. 1443214-97-8

  • Cat. No. CS-0905379
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Dibromomaleimide-C5-COOH|CS-0905379

Structure of 1443214-97-8

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General Information

  • CAS No. 1443214-97-8
  • Cat. No. CS-0905379
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁Br₂NO₄
  • Molecular Weight 369.01
  • Synonym(s) DBM-C5-COOH
  • SMILES O=C(CCCCCN1C(C(Br)=C(C1=O)Br)=O)O

Description

Dibromomaleimide-C5-COOH is a bifunctional crosslinker featuring maleimide and carboxylic acid handles. The maleimide moiety selectively reacts with thiols under physiological conditions, while the C5 spacer provides optimal flexibility for conjugation. This derivative enables efficient bioconjugation in antibody-drug conjugates and peptide-protein labeling workflows.

Application

Dibromomaleimide-C5-COOH serves as a versatile bifunctional building block for the synthesis of conjugated polymers and bioconjugates. Its maleimide moiety enables efficient Michael addition with thiols under physiological conditions, while the C5-carboxylic acid facilitates coupling via amine-reactive esters or carbodiimide chemistry. The molecule exhibits good bench stability and compatibility with diverse functional groups, enabling modular assembly in peptide-drug conjugates and surface-functionalized materials.

Safety Information

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Computational Chemistry Data

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  • Rotatable_Bonds   N/A

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