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(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopiperidin-3-yl)propanoate

  • CAS No. 1442483-69-3

  • Cat. No. CS-0376435
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopiperidin-3-yl)propanoate|CS-0376435

Structure of 1442483-69-3

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General Information

  • CAS No. 1442483-69-3
  • Cat. No. CS-0376435
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₄N₂O₅
  • Molecular Weight 300.35
  • Synonym(s) None
  • SMILES O=C(OC)[C@@H](NC(OC(C)(C)C)=O)C[C@H](CCCN1)C1=O

Description

(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopiperidin-3-yl)propanoate is a chiral dipeptide surrogate featuring a protected α-amino group and a reactive ketone-bearing piperidine ring. This configuration enables direct incorporation into peptide synthesis workflows, where the oxopiperidinyl moiety facilitates cyclization or downstream functionalization under standard conditions. The tert-butyl carbamate group ensures stability during handling and purification.

Application

(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopiperidin-3-yl)propanoate serves as a key chiral building block for the synthesis of piperidine-containing peptidomimetics and bioactive heterocycles. The protected amino group enables orthogonal deprotection, while the oxopiperidinyl moiety facilitates ring expansion or cyclization reactions. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for modular peptide and medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   93.73
  • LogP   0.969
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   4

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