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CS-W001157 4
Total: USD 88.00

3-(Aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one

  • CAS No. 1438382-15-0

  • Cat. No. CS-0137803
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one|CS-0137803

Structure of 1438382-15-0

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General Information

  • CAS No. 1438382-15-0
  • Cat. No. CS-0137803
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₂O₂
  • Molecular Weight 168.19
  • Synonym(s) 3-(Aminomethyl)-4-methoxy-6-methylpyridin-2-ol
  • SMILES O=C1C(CN)=C(OC)C=C(C)N1

Description

3-(Aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one features a pyridinone core functionalized with a methoxy group at C4, a methyl substituent at C6, and a strategically positioned aminomethyl side chain. This combination imparts enhanced solubility and metabolic stability, enabling efficient incorporation into bioactive scaffolds. The molecule serves as a key building block for targeted kinase inhibitors and medicinal chemistry campaigns requiring nitrogen-rich heterocycles with tunable polarity.

Application

3-(Aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to pyridone-based scaffolds. Its aminomethyl group facilitates downstream functionalization via alkylation or reductive amination, while the methoxy and methyl substituents enhance solubility and metabolic stability. The compound exhibits bench stability and compatibility with standard coupling protocols, making it suitable for parallel synthesis campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   68.11
  • LogP   0.15062
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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