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CS-W001157 4
Total: USD 88.00

2,4-Difluoro-3-iodoaniline

  • CAS No. 1437316-91-0

  • Cat. No. CS-0029695
  • Purity≥97%
  • MDL No.MFCD28789174

*For research and further manufacturing use only, not for direct human use.

2,4-Difluoro-3-iodoaniline|CS-0029695

Structure of 1437316-91-0

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General Information

  • CAS No. 1437316-91-0
  • Cat. No. CS-0029695
  • Purity ≥97%
  • MDL No. MFCD28789174
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₂IN
  • Molecular Weight 255.00
  • Synonym(s) None
  • SMILES NC1=CC=C(F)C(I)=C1F

Description

2,4-Difluoro-3-iodoaniline features a trifunctional aromatic core with fluorine and iodine substituents positioned for selective cross-coupling reactions. The electron-deficient ring enables efficient palladium-catalyzed transformations, while the ortho-fluorines enhance metabolic stability. This bench-stable intermediate integrates readily into complex molecular architectures.

Application

2,4-Difluoro-3-iodoaniline serves as a versatile building block for Suzuki-Miyaura and Buchwald-Hartwig coupling reactions, enabling the construction of biologically relevant arylated scaffolds. The ortho-fluoro groups enhance reactivity in palladium-catalyzed cross-couplings, while the iodine functionality provides high chemoselectivity and stability under standard reaction conditions. Its bench-stable nature and compatibility with diverse functional groups make it ideal for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.1516
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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