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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-nitrophenylboronic acid

  • CAS No. 1436608-93-3

  • Cat. No. CS-0178344
  • Molecule weight184.92
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-nitrophenylboronic acid|CS-0178344

Structure of 1436608-93-3

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General Information

  • CAS No. 1436608-93-3
  • Cat. No. CS-0178344
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BFNO₄
  • Molecular Weight 184.92
  • Synonym(s) (2-Fluoro-4-nitrophenyl)boronic acid
  • SMILES OB(C1=CC=C([N+]([O-])=O)C=C1F)O

Description

2-Fluoro-4-nitrophenylboronic acid features a boronate moiety flanked by electron-withdrawing fluorine and nitro groups, enhancing its reactivity in Suzuki-Miyaura couplings. The para-nitro substitution stabilizes the boronic acid under standard conditions while enabling selective functionalization. This bench-stable reagent integrates readily into complex molecule synthesis with high chemoselectivity.

Application

2-Fluoro-4-nitrophenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The ortho-fluoro and para-nitro substituents provide orthogonal reactivity, allowing sequential functionalization in complex molecule synthesis. Its bench-stable nature and compatibility with diverse reaction partners make it well-suited for pharmaceutical and agrochemical intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   83.6
  • LogP   -0.5863
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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