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Structure of 143540-05-0
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di-tert-Butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate features a sterically shielded piperazine core with two tert-butyl ester groups and a pendant hydroxymethyl handle. This combination delivers enhanced stability and solubility in organic media, enabling straightforward functionalization in synthetic sequences. The protected hydroxyl group facilitates selective derivatization while maintaining structural integrity under standard conditions.
di-tert-Butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate serves as a versatile building block for piperazine-based scaffolds in medicinal chemistry. The protected piperazine core enables orthogonal functionalization, while the hydroxymethyl group facilitates downstream derivatization via oxidation or substitution. Bench-stable and readily purified by standard chromatography, it functions effectively in multi-step syntheses requiring precise control over nitrogen functionality and stereochemical integrity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: