2-Phenoxyacetic anhydride

Name: 2-Phenoxyacetic anhydride
Brand: ChemScene
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CAS No. 14316-61-1
Cat. No. CS-0020049
Purity≥98%
MDL No.MFCD00059681

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 14316-61-1

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Description

2-Phenoxyacetic anhydride delivers a reactive acylating agent for selective esterification of alcohols and phenols under mild conditions. The phenoxyacetyl moiety integrates readily into bioactive scaffolds, while the anhydride functionality enables efficient coupling without requiring additional catalysts. This bench-stable reagent simplifies synthesis workflows in pharmaceutical and agrochemical development.

Application

2-Phenoxyacetic anhydride serves as a versatile acylating agent for the selective introduction of the phenoxyacetyl group into organic molecules. It facilitates efficient amide and ester formation under mild conditions, exhibits good bench stability, and enables straightforward purification due to low volatility. Its reactivity profile supports robust functionalization in synthetic pathways involving amino acids, nucleophiles, and heterocyclic intermediates, making it a practical choice for building blocks in medicinal chemistry and agrochemical synthesis.

General Information

CAS No. 14316-61-1
Cat. No. CS-0020049
Purity ≥98%
MDL No. MFCD00059681
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₄O₅
Molecular Weight None
Synonym(s) Phenoxyacetic anhydride
SMILES O=C(OC(COC1=CC=CC=C1)=O)COC2=CC=CC=C2

Computational Chemistry Data

TPSA 61.83
LogP 2.2142
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-Phenoxyacetic anhydride

CAS No. 14316-61-1

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