N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Name: N-(2-hydroxyethyl)-4-methylbenzenesulfonamide
Brand: ChemScene
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CAS No. 14316-14-4
Cat. No. CS-0316478
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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N-(2-hydroxyethyl)-4-methylbenzenesulfonamide|CS-0316478

Structure of 14316-14-4

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General Information

CAS No. 14316-14-4
Cat. No. CS-0316478
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₃NO₃S
Molecular Weight 215.27
Synonym(s) Benzenesulfonamide, N-(2-hydroxyethyl)-4-methyl-
SMILES CC1=CC=C(C=C1)S(=O)(=O)NCCO

Description

N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide features a hydrophilic hydroxyethyl chain appended to a sulfonamide group attached to a methyl-substituted benzene ring. This structure enhances solubility while maintaining metabolic stability, enabling efficient incorporation into bioconjugation workflows and medicinal chemistry campaigns requiring polar, bench-stable linkers.

Application

N-(2-Hydroxyethyl)-4-methylbenzenesulfonamide serves as a versatile sulfonamide building block in medicinal chemistry, enabling the introduction of both hydrophilic and hydrogen-bonding functionalities. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate efficient incorporation into target molecules. The pendant hydroxyl group provides additional handle for derivatization or conjugation, enhancing solubility and metabolic profile in lead optimization campaigns.

Synthesis

Route1
- 141-43-5
- 98-59-9
- ~99%
- In-stock
  
  14316-14-4
References
- Law, Katherine R.; McErlean, Christopher S. P. Chemistry - A European Journal, 2013 , vol. 19, # 47 p. 15852 - 15855
Route2
- 141-43-5
- In-stock
  
  2232-08-8
- ~94%
- In-stock
  
  14316-14-4
References
- Verma, Sanjeev K.; Acharya; Kaushik Organic Letters, 2010 , vol. 12, # 19 p. 4232 - 4235
Route3
- 141-43-5
- 98-09-9
- ~92%
- In-stock
  
  14316-14-4
References
- Tamaddon, Fatemeh; Nasiri, Alireza; Farokhi, Somayeh Catalysis Communications, 2011 , vol. 12, # 15 p. 1477 - 1482

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.4
LogP 0.26562
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Sulfonamide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

CAS No. 14316-14-4

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