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CS-W001157 4
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7-Chloro-[1,2,4]triazolo[1,5-a]pyridine

  • CAS No. 1427452-48-9

  • Cat. No. CS-0136597
  • Molecule weight153.57
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Chloro-[1,2,4]triazolo[1,5-a]pyridine|CS-0136597

Structure of 1427452-48-9

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General Information

  • CAS No. 1427452-48-9
  • Cat. No. CS-0136597
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClN₃
  • Molecular Weight 153.57
  • Synonym(s) 7-Chloro[1,2,4]triazolo[1,5-a]pyridine
  • SMILES ClC1=CC2=NC=NN2C=C1

Description

7-Chloro-[1,2,4]triazolo[1,5-a]pyridine is a heterocyclic scaffold featuring a fused triazolopyridine core with a chlorine substituent at the 7-position. This electron-deficient system enables efficient coupling in transition-metal-catalyzed reactions and serves as a key building block in medicinal chemistry for constructing bioactive molecules.

Application

7-Chloro-[1,2,4]triazolo[1,5-a]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of bioactive scaffolds. Its chlorine substituent facilitates palladium-catalyzed cross-coupling reactions and nucleophilic substitution, while the fused triazolopyridine core offers enhanced metabolic stability and favorable binding interactions. The compound exhibits excellent bench stability and ease of purification, making it well-suited for scalable synthesis and parallel library development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.3827
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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