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CS-W001157 4
Total: USD 88.00

DBCO-​C6-​acid

  • CAS No. 1425485-72-8

  • Cat. No. CS-0083330
  • Purity≥97%
  • MDL No.MFCD22380737

*For research and further manufacturing use only, not for direct human use.

DBCO-​C6-​acid|CS-0083330

Structure of 1425485-72-8

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General Information

  • CAS No. 1425485-72-8
  • Cat. No. CS-0083330
  • Purity ≥97%
  • MDL No. MFCD22380737
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₁₉NO₃
  • Molecular Weight 333.38
  • Synonym(s) None
  • SMILES O=C(CCCCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3

Description

DBCO-C6-acid features a reactive cyclooctyne moiety linked via a six-atom aliphatic chain to a carboxylic acid group. This structure enables efficient copper-free bioconjugation while providing a handle for further derivatization or immobilization through amide bond formation. The C6 spacer offers enhanced solubility and reduced steric interference compared to shorter linkers.

Application

DBCO-C6-acid serves as a versatile bioorthogonal building block, enabling efficient copper-free click conjugation via strain-promoted cycloaddition. The C6 linker provides optimal spacing for reduced steric hindrance, while the carboxylic acid functionality facilitates direct amide coupling or activation for further derivatization. This reagent exhibits excellent stability under physiological conditions and simplifies purification in biomolecule labeling workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   57.61
  • LogP   3.578
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   5

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